Association of combined allergic diseases, asthma, eczema-urticaria and hay fever with sibship size, birth order and childhood socio-economic position
| Crude | Partially adjusted* | Fully adjusted† | |||||||
|---|---|---|---|---|---|---|---|---|---|
| OR | 95% CI | ptrend | OR | 95% CI | ptrend | OR | 95% CI | ptrend | |
| OR, odds ratio; 95% CI, 95% confidence intervals. | |||||||||
| *Adjusted for age, sex, year of birth, year of examination, and family history of allergy. | |||||||||
| †Adjusted for sibship size, birth order, childhood socioeconomic position, age, sex, year of birth, year of examination, and family history of allergy. | |||||||||
| Eczema-urticaria | |||||||||
| Sibship size | |||||||||
| 0 | 1 | 1 | 1 | ||||||
| 1 | 0.98 | (0.78 to 1.22) | 0.94 | (0.75 to 1.17) | 0.89 | (0.70 to 1.14) | |||
| 2 | 0.75 | (0.58 to 0.98) | 0.71 | (0.55 to 0.92) | 0.67 | (0.50 to 0.90) | |||
| 3+ | 0.81 | (0.63 to 1.06) | 0.024 | 0.73 | (0.56 to 0.96) | 0.003 | 0.71 | (0.52 to 0.97) | 0.007 |
| Birth order | |||||||||
| 1 | 1 | 1 | 1 | ||||||
| 2 | 1.03 | (0.85 to 1.24) | 1.02 | (0.84 to 1.23) | 1.10 | (0.89 to 1.36) | |||
| 3+ | 0.84 | (0.66 to 1.06) | 0.247 | 0.82 | (0.64 to 1.04) | 0.178 | 1.03 | (0.77 to 1.38) | 0.658 |
| Childhood socioeconomic position | |||||||||
| I | 1 | 1 | 1 | ||||||
| II | 0.84 | (0.68 to 1.04) | 0.84 | (0.68 to 1.05) | 0.84 | (0.68 to 1.04) | |||
| III | 0.76 | (0.61 to 0.94) | 0.80 | (0.64 to 1.00) | 0.80 | (0.64 to 1.00) | |||
| IV–V | 0.67 | (0.46 to 0.99) | 0.006 | 0.75 | (0.51 to 1.11) | 0.045 | 0.77 | (0.52 to 1.14) | 0.054 |
| Hay fever | |||||||||
| Sibship size | |||||||||
| 0 | 1 | 1 | 1 | ||||||
| 1 | 0.79 | (0.66 to 0.95) | 0.74 | (0.62 to 0.89) | 0.76 | (0.62 to 0.92) | |||
| 2 | 0.76 | (0.62 to 0.93) | 0.68 | (0.55 to 0.83) | 0.73 | (0.59 to 0.92) | |||
| 3+ | 0.60 | (0.48 to 0.75) | <0.001 | 0.55 | (0.44 to 0.68) | <0.001 | 0.63 | (0.49 to 0.82) | 0.001 |
| Birth order | |||||||||
| 1 | 1 | 1 | 1 | ||||||
| 2 | 0.83 | (0.71 to 0.98) | 0.82 | (0.70 to 0.96) | 0.91 | (0.76 to 1.08) | |||
| 3+ | 0.64 | (0.52 to 0.78) | <0.001 | 0.63 | (0.51 to 0.77) | <0.001 | 0.78 | (0.61 to 1.00) | 0.041 |
| Childhood socioeconomic position | |||||||||
| I | 1 | 1 | 1 | ||||||
| II | 0.87 | (0.73 to 1.03) | 0.88 | (0.74 to 1.05) | 0.89 | (0.74 to 1.06) | |||
| III | 0.63 | (0.53 to 0.76) | 0.65 | (0.54 to 0.78) | 0.65 | (0.54 to 0.79) | |||
| IV–V | 0.56 | (0.40 to 0.78) | <0.001 | 0.59 | (0.42 to 0.83) | <0.001 | 0.61 | (0.44 to 0.86) | <0.001 |