Percentage reduction in annual exacerbation rate in major studies
| Study | Reference | Treatment | Effect (%) |
|---|---|---|---|
| Comb, combination of β2 agonist and inhaled steroid; NAC, N-acetylcysteine. | |||
| EUROSCOP | Pauwels et al1 | Budesonide/placebo | 0 |
| ISOLDE | Burge et al3 | Fluticasone/placebo | 25 |
| Copenhagen City Lung Study | Vestbo et al2 | Budesonide/placebo | 0 |
| LHS II | LHS Group4 | Triamcinalone/placebo | – |
| TRISTAN | Calverley et al8 | Comb/placebo | 25 |
| Symbicort | Szafranski et al7 | Comb/placebo | 24 |
| Calverley et al8 | Comb/placebo | 23 | |
| Tiotropium | Vincken et al5 | Tiotropium/ipratropium | 24 |
| Casaburi et al6 | Tiotropium/placebo | 20 | |
| BRONCUS | Decramer et al60 | NAC/placebo | 22 |
| Rehabilitation | Griffiths et al82 | Rehabilitation/placebo | 26 |