Table 2
Response to treatment
Measurement | Sildenafil 25 mg (n = 9) | Sildenafil 100 mg (n = 5) | Placebo (n = 8) |
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Pre-treatment | Week 12 | Pre-treatment | Week 12 | Pre-treatment | Week 12 |
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Baseline | Baseline | 1 h post-dose | Baseline | Baseline | 1 h post-dose | Baseline | Baseline | 1 h post-dose |
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mPAP (mm Hg) | 36 (8) | 30 (8) | 25 (7) | 32 (3) | 26 (3) | 21 (2) | 34 (6) | 35 (12) | 35 (11) |
Syst PAP (mm Hg) | 53 (11) | 47 (13) | 39 (10) | 46 (5) | 41 (6) | 33 (4) | 51 (7) | 55 (19) | 55 (18) |
CO (l/min) | 5.3 (1.1) | 5.0 (1.4) | 5.4 (1.7) | 5.5 (1.2) | 6.6 (0.6) | 6.4 (0.8) | 4.6 (1.2) | 5.3 (1.7) | 5.3 (1.6) |
PVR (dyne.s/cm5) | 441 (242) | 391 (243) | 284 (204) | 328 (58) | 185 (49) | 130 (39) | 457 (146) | 390 (205) | 388 (208) |
WP (mm Hg) | 9 (1) | 9 (2) | 9 (2) | 9.6 (2.1) | 11 (2.8) | 11 (2.8) | 9 (2) | 10 (3) | 10 (3) |
HR (beats/min) | 66 (8) | 63 (10) | 62 (9) | 74 (12) | 70 (14) | 69 (14) | 61 (5) | 63 (8) | 62 (8) |
SBP (mm Hg) | 127 (22) | 125 (19) | 124 (17) | 132 (20) | 127 (8) | 125 (7) | 118 (8) | 123 (13) | 123 (13) |
DBP (mm Hg) | 77 (10) | 78 (7) | 78 (7) | 80 (7) | 81 (2) | 81 (2) | 75 (5) | 75 (6) | 76 (6) |
Sao2 (%) | 94 (3) | 95 (2) | 95 (2) | 94 (2) | 95 (1) | 95 (1) | 94 (5) | 94 (5) | 94 (5) |