Demographic data and baseline characteristics of class III idiopathic PAH patients in matched cohorts
| N | Bosentan matched cohort(N = 83) | n | Epoprostenol matched cohort(N = 83) | p value* | |
|---|---|---|---|---|---|
| mPAP, mean pulmonary artery pressure; mRAP, mean right atrial pressure; PAH, pulmonary arterial hypertension; PVR, pulmonary vascular resistance; SD, standard deviation. | |||||
| Patients were matched using baseline cardiac index, mPAP, and mRAP (see Methods section in online supplement). | |||||
| *p values were determined using the Fisher’s exact test (sex) and the Student’s t test (all others). | |||||
| †For most bosentan treated patients, time from diagnosis and haemodynamic data were available only at the start of the placebo controlled study. | |||||
| Sex (M/F, %) | 83 | 24/76 | 83 | 28/72 | 0.723 |
| Age (years) | |||||
| Mean (SD) | 83 | 46 (16) | 83 | 43 (13) | 0.136 |
| Range | 13–76 | 15–74 | |||
| Time from diagnosis (months)* | |||||
| Mean (SD) | 83 | 29 (36) | 26 | 11 (19) | 0.014 |
| Range | 1–173 | 0–92 | |||
| Haemodynamics (mean (SD))† | |||||
| Cardiac index (l/min/m2) | 83 | 2.2 (0.6) | 83 | 2.1 (0.6) | 0.610 |
| PVR (Wood units) | 79 | 13 (6) | 53 | 14 (6) | 0.553 |
| mPAP (mm Hg) | 83 | 57 (15) | 83 | 59 (15) | 0.397 |
| mRAP (mm Hg) | 83 | 10 (5) | 83 | 10 (5) | 0.893 |
| Walk test (m) | |||||
| Mean (SD) | 83 | 355 (76) | 41 | 350 (110) | 0.762 |