Global results of immunohistochemical analysis
| Controls(n = 6 or 7) | Moderate asthma(n = 6 or 7) | Severe asthma(n = 9) | p value* | |
|---|---|---|---|---|
| Data are shown as median (interquartile range). | ||||
| *Analysis of variance using the Kruskal-Wallis rank test. | ||||
| Lamina reticularis(μm) | 2.60 (2.46–2.65) | 4.11 (3.02–4.96) | 4.41 (4.02–4.96) | 0.01 |
| Submucosal collagen III (%) | 32.2 (18.0–36.7) | 60.4 (44.9–64.4) | 56.4 (53.5–61.1) | 0.007 |
| Submucosal EG2+ve (cells/mm2) | 16.9 (13.7–75.5) | 30.9 (14.7–71.6) | 41.4 (19.7–105.8) | 0.692 |
| EGFR (% intact epithelium) | 47.4 (46.4–49.7) | 86.4 (79.8–89.9) | 86.4 (83.3–89.4) | 0.002 |
| p21 (% intact epithelium) | 23.7 (16.8–41.0) | 82.5 (75.3–87.4) | 87.9 (81.0–89.0) | 0.004 |
| MIB-1 (% intact epithelium) | 26.3 (17.9–27.7) | 2.3 (1.2–5.1) | 0.9 (0.17–2.0) | 0.001 |