Scores on questionnaires in patients with sarcoidosis and healthy subjects
| Sarcoidosis | Healthy subjects | Differences between medians (95% CI) | p value | ||
|---|---|---|---|---|---|
| Values are expressed as median (interquartile range) and as differences between medians (95% CI). Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36) included eight multiple item scales. Scores can range from 0 (worst) to 100 (optimal). The Hospital Anxiety and Depression Scale (HADS) included seven questions related to anxiety and seven related to depression. Each item is rated on 4-point scale (0–3) giving maximum scores of 21 for anxiety and depression, respectively. A score of >10 points is suggestive for the clinical presence of anxiety or depression. EQ-5D is expressed as a number of patients or healthy subjects who have none or some or severe problems on the five domains. n = 20 healthy subjects for all questionnaires. | |||||
| SF-36 (0–100) | |||||
| Physical functioning | 45 (35–70) | 95 (90–100) | 50 (25 to 65) | 0.0001 | |
| Role functioning physical | 0 (0–50) | 100 (100–100) | 100 (50 to 100) | 0.0001 | |
| Bodily pain | 50 (40–60) | 80 (70–100) | 30 (20 to 60) | 0.0009 | |
| General health | 30 (20–60) | 80 (65–85) | 50 (15 to 60) | 0.0001 | |
| Vitality | 45 (30–60) | 80 (65–85) | 35 (15 to 50) | 0.0001 | |
| Social functioning | 62.5 (50–88) | 100 (88–100) | 37.5 (12.5 to 50) | 0.0002 | |
| Role functioning emotional | 100 (33–100) | 100 (100–100) | 0 (0 to 33.3) | 0.02 | |
| Mental health | 64 (44–80) | 88 (80–92) | 24 (4 to 44) | 0.0001 | |
| EQ-5D (none/some or severe) | |||||
| Mobility | 14/8 | 19/1 | – | 0.02 | |
| Self-care | 19/3 | 20/0 | – | 0.095 | |
| Usual activities | 7/15 | 19/1 | – | 0.001 | |
| Pain/discomfort | 4/18 | 16/4 | – | 0.001 | |
| Anxiety/depression | 15/7 | 18/2 | – | 0.101 | |
| Visual analogue scale | 65 (40–85) | 83 (66–97) | 18 (7 to 30) | 0.0001 | |
| HADS (0–21) | |||||
| Anxiety | 7 (5–10) | 3 (1–5) | −4 (−8 to −2) | 0.0002 | |
| Depression | 7 (3–11) | 0 (0–1) | −7 (−11 to −3) | 0.0001 | |