Tier 1 studies† |
Harrow et al28‡ | 2000 | 34 | 100 | 8 | 17 | 1 | 48 | Patients with suspected lung cancer were included. Patients without lung cancer, or TBNA from a lymph node confluent with the tumour mass were excluded by the authors. |
Bilaceroglu et al29‡ | 1998 | 60 | 100 | 24 | 9 | 0 | 22 | Patients with potentially resectable extrabronchial or endobronchial mass suggestive of lung cancer and without extrathoracic metastases were included. We excluded patients with N0 or N1 disease on pre-TBNA CT.¶ |
Disdier et al30 | 1998 | 52 | 100 | 5 | 9 | 1 | 12 | Patients with potentially resectable lung cancer without evidence of extrathoracic metastases and with enlarged mediastinal LAD on CT or CXR were included. |
Ratto et al31 | 1988 | 30 | 96 | 2 | 12 | 0 | 33 | Patients with potentially resectable lung cancer (no preoperative SCLC) without evidence of extrathoracic metastases were included. Only subcarinal lymph nodes were biopsied. |
Schenk et al32‡ | 1986 | 29 | 100 | 8 | 13 | 2 | 50 | Patients with CXR evidence of lung cancer and who were potentially resectable without evidence of extrathoracic metastases were included. One FP had scanty neoplastic cells without lymphocytes. |
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Studies not meeting tier 1 criteria
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Herth et al33‡ ** | 2002 | 82 | 100 | 30 | 6 | 0 | 8 | Patients with central lung cancer and enlarged mediastinal LAD by CT without evidence of extrathoracic metastases were included. Needle placement via endobronchial ultrasound. |
Wang et al34 | 2002 | 100 | 93†† | 10 | 0 | 0 | 0 | Inclusion criteria not specified. Unable to calculate specificity (100% prevalence). |
Patelli et al35 | 2002 | NA | 100 | 127 | 52 | – | 15 | Patients with NSCLC, N2 disease by CT scanning and a negative bronchoscopy for lung cancer were included. Statistical analysis was by TBNA specimen. Data were collected by retrospective chart review. Non-surgically confirmed negative TBNA specimens (total 49) were assumed to be false negative. |
Katis et al36 | 1998 | 95 | 100 | 28 | 8 | – | 2 | Patients with CXR evidence of lung cancer and enlarged mediastinal LAD on CT and who were potentially resectable and without evidence of extrathoracic metastases were included. |
Rong et al37‡ ** | 1998 | 79 | 100 | 26 | 2 | 0 | 5 | Patients undergoing thoracotomy for mediastinal adenopathy on CT and suspected lung cancer were included. Bronchoscopist was not experienced with TBNA. Real-time CT assisted needle placement. |
Schenk et al38 | 1993 | 81 | 100 | 32 | 6 | – | 9 | Patients with resectable lung cancer and paratracheal LAD without extrathoracic metastases were included. Four of the 32 TPs were confirmed surgically. |
Schenk et al39 | 1989 | 81 | 100 | 14 | 3 | – | 4 | Patients with CXR evidence of lung cancer and who were potentially resectable and without evidence of extrathoracic metastases were included. |
Wang et al40 | 1983 | 55 | 100 | 13 | 3 | – | 13 | Patients with suspected lung cancer and who were potentially resectable and without evidence of extrathoracic metastases were included. |