Characteristics of study subjects
| COPD(n = 29) | Healthy subjects(n = 18) | Mean difference(95% CI) | p value | |
|---|---|---|---|---|
| Values are mean (SE). | ||||
| BMI, body mass index; FEV1, forced expiratory volume in 1 second; FVC, forced vital capacity; TLC, total lung capacity; Tlco, lung carbon monoxide transfer factor; Pao2, arterial oxygen tension; Paco2, arterial carbon dioxide tension; Sao2, arterial oxygen saturation; Vo2, oxygen consumption. | ||||
| *Based on the predicted equation of Jones.16 | ||||
| Age (years) | 65 (1) | 62 (1) | 3 (−1 to 7) | NS |
| BMI (kg/m2) | 25 (1) | 26 (1) | 1 (−2 to 5) | NS |
| FEV1 (l) | 0.94 (0.09) | 2.86 (0.07) | 1.91 (1.61 to 2.22) | <0.001 |
| FEV1 (% pred) | 37 (3) | 110 (4) | 72 (63 to 82) | <0.001 |
| FVC (l) | 2.19 (0.15) | 3.82 (0.11) | 1.63 (1.12 to 2.14) | <0.001 |
| FVC (% pred) | 59 (3) | 101 (4) | 42 (32 to 52) | <0.001 |
| TLC (% pred) | 124 (4) | 99 (3) | 24 (10 to 38) | <0.01 |
| Tlco (% pred) | 56 (6) | 111 (3) | 54 (35 to 73) | <0.001 |
| Resting Pao2 (kPa) | 10.4 (0.3) | 12.8 (0.4) | 2.4 (1.1 to 3.6) | <0.001 |
| Resting Paco2 (kPa) | 5.6 (0.1) | 5.2 (0.1) | 0.4 (−0.2 to 1.0) | NS |
| Resting Sao2 (%) | 95 (0) | 98 (0) | 3 (1 to 4) | <0.001 |
| Peak Vo2 (ml/kg/min) | 14 (1) | 28 (2) | 14 (10 to 18) | <0.001 |
| Peak Vo2 (% pred)* | 66 (6) | 103 (6) | 37 (18 to 55) | <0.001 |