Details of lung samples used for isolated perfused human lung experiments and characteristics of patients from whom the tissue was obtained
| Lung specimen | Age (years) | Sex | Medical history | Medication | Anaesthesia and analgesia | Peptide studied | |||
|---|---|---|---|---|---|---|---|---|---|
| Chemical name | Class of drug | Anaesthetic regimen | Analgesic regimen | Other agents | |||||
| LL = left lung; LLL = left lower lobe; LUL = left upper lobe; RL = right lung; RLL = right lower lobe; RUL = right upper lobe; RML = right middle lobe; NSAID = non-steroidal anti-inflammatory drug; COPD = chronic obstructive pulmonary disease; IHD = ischaemic heart disease. | |||||||||
| All patients received cefamandole in addition to one of the following anaesthetic regimens: | |||||||||
| A: inhaled anaesthetic: isofluorane + nitrous oxide, iv anaesthetic: thiopental, non-depolarising muscle relaxant: atracurium; | |||||||||
| B: inhaled anaesthetic: sevafluorane, iv anaesthetic: propofol, non-depolarising muscle relaxant: vencuronium bromide; | |||||||||
| C: inhaled anaesthetic: isofluorane + nitrous oxide, iv anaesthetic: propofol, non-depolarising muscle relaxant: atracurium) | |||||||||
| and one of the following analgesic regimens: | |||||||||
| D: morphine + temazepam; | |||||||||
| E: morphine + lorazepam; | |||||||||
| F: morphine + papavatetum + lorazepam; | |||||||||
| G: morphine + fentanyl; | |||||||||
| H morphine + papavatetum. | |||||||||
| L5 (LL) | 70 | M | Asthma | Paracetamol | Non-opioid analgesic | A | F | ET-1 | |
| Psoriasis | Ibuprofen | NSAID | |||||||
| Cefotaxime | Cephalosporin | ||||||||
| Heparin sodium | Anticoagulant | ||||||||
| Co-amoxiclav | Penicillin | ||||||||
| Diclofenac | NSAID | ||||||||
| Salbutamol | β2 agonist | ||||||||
| Iprotropium bromide | Muscarinic antagonist | ||||||||
| L6 (RUL) | 71 | F | Hypertensive goitre | Salbutamol | β2 agonist | A | F | ET-1 | |
| Heparin sodium | Anticoagulant | ||||||||
| Co-amoxiclav | Penicillin | ||||||||
| Nifedipine | Calcium antagonist | ||||||||
| Nitrazepam | Benzodiazepine | ||||||||
| Thyroxine | Thyroid hormone | ||||||||
| L8 (LL) | 53 | F | None | Dihydrocodeine | Opioid analgesic | A | F | ET-1 | |
| L9 (RUL) | 73 | M | Ex-smoker | Beclomethasone | Corticosteroid | C | H | Hyoscine | ET-1 |
| L10 (RUL) | 73 | F | Asthma | Salbutamol | β2 agonist | C | D | Metoclopramide | ET-3 |
| Budesonide | Corticosteroid | ||||||||
| Oxitropium | Antimuscarinic bronchodilator | ||||||||
| Bumetadine | Loop diuretic | ||||||||
| L11 (LL) | 70 | M | Gout | Allopurinol | Xanthine oxidase inhibitor | A | F | ET-3 | |
| L13 (RLL) | 58 | M | Hypertension | Prazosin | α1 antagonist | C | H | Hyoscine | ET-3 |
| Prednisolone | Glucocorticoid | ||||||||
| Amlodipine | Calcium antagonist | ||||||||
| Beclomethasone | Antimuscarinic bronchodilator | ||||||||
| Oxitropium | |||||||||
| L14 (RL) | 69 | M | Adrenocarcinoma | Glycerol trinitrate | NO donor | A | F | ET-3 | |
| IHD | Furosemide | Loop diuretic | |||||||
| Acetylsalicylic acid | Non-opioid analgesic | ||||||||
| Atenolol | β2 antagonist | ||||||||
| L15 (LUL) | 65 | M | COPD | Salbutamol | β2 agonist | C | E | ET-3 | |
| Peripheral vascular disease | Glibenclamide | Potassium channel blocker | |||||||
| Diabetes mellitus | Acetylsalicylic acid | Non-opioid analgesic | |||||||
| Glycerol trinitrate | No donor | ||||||||
| Beclomethasone | Corticosteroid | ||||||||
| L16 (RML) | 69 | M | Smoker | None | A | F | ET-1 | ||
| L25 (LLL) | 56 | M | Asthma | Salbutamol | β2 agonist | B | G | Hyoscine | ET-3 |
| COPD | Iprotopium bromide | Muscarinic antagonist | |||||||
| Co-amoxiclav | Penicillin | ||||||||
| Paracetamol | Non-opioid analgesic | ||||||||
| L28 (RLL) | 65 | F | Pulmonary embolus | Salbutamol | β2 agonist | A | F | ET-1 | |
| Heparin sodium | Anticoagulant | ||||||||
| Co-proxamol | NSAID | ||||||||
| Naproxen | NSAID | ||||||||
| L29 (LLL) | 68 | F | None | None | B | G | Hyoscine | hUII/ET-1 | |
| L30 (LLL) | 68 | F | Asthma | Salmeterol | β2 agonist | B | G | Hyoscine | hUII/ET-1 |
| Hypertension | Beclomethasone | Corticosteroid | |||||||
| Smoker | Diazepam | Benzodiazepine | |||||||
| COPD | Dalteparin | Heparin | |||||||
| Cefotaxime | Cephalosporin | ||||||||
| Furosemide | Loop diuretic | ||||||||
| L31 (LL) | 71 | M | COPD | Dalteparin | Heparin | B | G | Hyoscine | hUII/ET-1 |
| Cefotaxime | Cephalosporin | ||||||||
| Paracetamol | Non-opioid analgesic | ||||||||
| Dihydrocodeine | Opioid analgesic | ||||||||