Biochemical markers of systemic inflammation, clinical characteristics, and annual change in bone mineral content in men and women with cystic fibrosis
| Men | Women | p value | |
|---|---|---|---|
| IL-6 = interleukin 6; CRP = C reactive protein; FEV1 = forced expiratory volume in 1 second; BMI = body mass index; BMC = bone mineral content. | |||
| *Mann-Whitney U test. | |||
| †Unpaired Student’s t test. | |||
| Median (IQR) IL-6 (pg/ml) | 7.2 (4.1–13.6) | 3.9 (1.8–6.4) | 0.007* |
| Median (IQR) CRP (mg/l) | 20.0 (7.5–28.0) | 5.5 (5.0–23.5) | 0.01* |
| Median (IQR) intravenous antibiotic use (days) | 23 (0–43) | 26 (2–67) | 0.51* |
| Median prednisolone use (mg/day) | 0.7 (0–2.5) | 0.6 (0–2.0) | 0.58* |
| Mean (SD) physical activity score (3–15) | 7.8 (1.3) | 7.8 (0.9) | 0.81† |
| Mean (SD) baseline FEV1 (% predicted) | 60.9 (24.3) | 63.0 (24.1) | 0.66† |
| Mean (SD) annual change in FEV1 (% predicted) | −1.2 (8.8) | −3.0 (7.5) | 0.27† |
| Mean (SD) annual change in BMI (kg/m2) | 0.26 (1.05) | 0.15 (1.10) | 0.61† |
| Mean (SD) annual change in bone mineral content (%) | −0.83 (3.30) | −0.42 (2.20) | 0.47† |