Genotype distribution and rare allele frequency (%) of the −915A>G and −1296T>C variants in Mexican healthy subjects, IPF, PBD and EA populations
| Category | n | Rare allele frequency (%) | Genotype (%) | p value† | |||
|---|---|---|---|---|---|---|---|
| (95% CI) | p value* | AA | AG | GG | |||
| H = healthy subjects; IPF = idiopathic pulmonary fibrosis; PBD = pigeon breeders’ disease; EA = subjects exposed to avian antigen but without PBD. | |||||||
| All genotypes were checked independently for accuracy. Both −915A>G and −1296T>C variants were in Hardy-Weinberg equilibrium in all four subject groups. χ2 values for –915A>G were: healthy subjects 2.37 (p = 0.12), IPF 0.03 (p = 0.87), PBD 1.61 (p = 0.21), and EA 0.20 (p = 0.65). χ2 values for −1296T>C were: healthy subjects 0.05 (p = 0.82), IPF 0.01 (p = 0.92), PBD 0.99 (p = 0.32), and EA 1.07 (p = 0.30). | |||||||
| *Allele and †genotype frequencies compared by χ2 test with healthy subjects (PBD subjects have also been compared by χ2 test with EA subjects and the p values are shown in parentheses). | |||||||
| −915A>G variant | |||||||
| H | 323 | 0.33 (0.29 to 0.37) | 139 (43.0) | 155 (48.0) | 29 (9.0) | ||
| IPF | 94 | 0.30 (0.23 to 0.36) | 0.71 | 46 (48.9) | 40 (42.6) | 8 (8.5) | 0.591 |
| PBD | 115 | 0.22 (0.17 to 0.28) | 0.009 (0.016) | 72 (62.6) | 35 (30.4) | 8 (7.0) | 0.001 (0.019) |
| EA | 90 | 0.35 (0.28 to 0.42) | 0.88 | 39 (43.3) | 39 (43.3) | 12 (13.3) | 0.434 |
| TT | TC | CC | |||||
| −1296T>C variant | |||||||
| H | 323 | 0.36 (0.32 to 0.39) | 133 (41.1) | 150 (46.4) | 40 (12.4) | ||
| IPF | 94 | 0.33 (0.26 to 0.40) | 0.80 | 42 (44.7) | 42 (44.7) | 10 (10.6) | 0.800 |
| PBD | 115 | 0.23 (0.18 to 0.28) | 0.002 (0.016) | 70 (60.9) | 37 (32.2) | 8 (7.0) | 0.001 (0.023) |
| EA | 90 | 0.36 (0.29 to 0.43) | 0.99 | 39 (43.3) | 37 (41.1) | 14 (15.6) | 0.588 |