Mean (SD) physical characteristics and bone parameters of study patients
| Treatment group (n = 35) | Control group (n = 24) | Non-study group (n = 55) | |||
|---|---|---|---|---|---|
| Baseline | Follow up | Baseline | Follow up | Baseline | |
| BMD = bone mineral density; BMC = bone mineral content; BMI = body mass index. | |||||
| *p<0.005 significantly younger than treatment/non-study group. | |||||
| †p<0.05, ††p<0.0001 significantly higher than treatment group. | |||||
| ‡p<0.005 significantly higher than treatment/non-study groups. | |||||
| Age (years) | 24.7 (6.2) | 27.0 (6.3) | 21.4 (4.0)* | 24.3 (4.7) | 24.5 (6.3) |
| Height (cm) | 165.7 (8.5) | 166.3 (8.9) | 164.7 (9.7) | 164.3 (9.2) | 164.5 (8.1) |
| Weight (kg) | 55.6 (8.9) | 55.9 (10.0) | 55.3 (10.4) | 55.9 (10.1) | 52.7 (8.4) |
| BMI (kg/m2) | 20.2 (2.1) | 20.1 (2.3) | 20.3 (2.5) | 20.6 (2.2) | 19.4 (2.4) |
| Duration of treatment (years) | 1.95 (0.4) | ||||
| Sex (F/M) | 15/20 | 16/8 | 30/25 | ||
| PA spine (L2–L4) | |||||
| BMC (g) | 41.0 (8.4) | 43.4(9.6) | 45.6 (9.3) | 45.9 (8.9) | 42.5 (8.2) |
| Area (cm2) | 40.6 (5.0) | 41.5 (5.3) | 40.1 (5.5) | 40.3 (5.4) | 40.0 (4.4) |
| BMD (g/cm2) | 1.001 (0.12) | 1.035 (0.13) | 1.131 (0.10)†† | 1.132 (0.10) | 1.059(0.14) |
| Z score | −1.8 (1.0) | −1.5 (1.1) | −0.7 (1.0)†† | −0.7 (0.8) | −1.2 (1.2) |
| Femoral neck | |||||
| BMC (g) | 4.2 (0.8) | 4.3 (0.7) | 4.7 (0.7) | 4.5 (0.7) | 4.3 (0.8) |
| Area (cm2) | 4.6 (0.5) | 4.7 (0.5) | 4.5 (0.5) | 4.5 (0.5) | 4.5 (0.4) |
| BMD (g/cm2) | 0.911 (0.13) | 0.910 (0.11) | 1.029 (0.08)†† | 0.987 (0.08) | 0.948 (0.15) |
| Z score | −1.1 (1.0) | −1.0 (0.8) | 0.0 (0.6)‡ | −0.3 (0.6) | −0.8 (1.2) |
| Total body | |||||
| BMC (g) | 2164 (384) | 2238 (438) | 2290 (469) | 2267 (462) | 2146 (411) |
| Area (cm2) | 1984 (255) | 2003 (279) | 2009 (285) | 1997 (278) | 1963 (254) |
| BMD (g/cm2) | 1.084 (0.07) | 1.110 (0.08) | 1.131 (0.08) | 1.128 (0.08) | 1.086 (0.09) |
| Z score | −1.15 (0.9) | −0.9 (0.9) | −0.4 (0.8)† | −0.4 (0.7) | −0.8 (1.2) |