Genotype and allele frequencies of endothelial nitric oxide synthase (eNOS) polymorphisms in highland dwellers (HLs), lowland dwellers (LLs) and patients with high altitude pulmonary oedema (HAPE)
| Polymorphism | Frequency distribution | ||||||
|---|---|---|---|---|---|---|---|
| HLs(n = 136) | LLs(n = 64) | HAPE(n = 59) | χ2 | p value | OR | 95% CI | |
| Glu298Asp | |||||||
| Glu298Glu | 105 (78%) | 39 (61%) | 22 (37%) | ||||
| Glu298Asp | 29 (21%) | 23 (36%) | 35 (59%) | ||||
| Asp298Asp | 2 (1%) | 2 (3%) | 2 (4%) | ||||
| Glu | 239 (88%) | 101(79%) | 79 (68%) | ||||
| Asp | 33 (12%) | 27 (21%) | 39 (32%) | ||||
| HLs v HAPE | |||||||
| Genotypes | 28.91 | 0.000001 | – | – | |||
| Alleles | 23.92 | 0.000001 | 3.58 | 2.11 to 6.07 | |||
| LLs v HAPE | |||||||
| Genotypes | 7.03 | 0.03 | – | – | |||
| Alleles | 4.47 | 0.03 | 1.85 | 1.04 to 3.27 | |||
| HLs v LLs | |||||||
| Genotypes | 5.77 | 0.05 | – | – | |||
| Alleles | 5.48 | 0.02 | 1.94 | 1.11 to 3.39 | |||
| 4b/4a | |||||||
| 4b/b | 113 (84%) | 45 (71%) | 31 (53%) | ||||
| 4b/a | 23 (16%) | 19 (29%) | 28 (47%) | ||||
| 4b | 249 (92%) | 109 (86%) | 90 (76%) | ||||
| 4a | 23 (8%) | 19 (14%) | 28 (24%) | ||||
| HLs v HAPE | |||||||
| Genotypes | 19.88 | 0.000008 | – | – | |||
| Alleles | 16.89 | 0.00004 | 3.51 | 1.84 to 6.15 | |||
| LLs v HAPE | |||||||
| Genotypes | 4.11 | 0.04 | – | – | |||
| Alleles | 3.14 | 0.08 | 1.78 | 0.94 to 3.41 | |||
| HLs v LLs | |||||||
| Genotypes | 4.28 | 0.04 | – | – | |||
| Alleles | 3.78 | 0.05 | 1.89 | 0.99 to 3.61 | |||