Changes in markers of bronchial inflammation from day 1 to the stable state
| Eradicated (n=28) | Persistent (n=18) | |||
|---|---|---|---|---|
| Day 1 | Stable state | Day 1 | Stable state | |
| Results are presented as median (interquartile range). | ||||
| MPO=myeloperoxidase; NE=neutrophil elastase; LTB4=leuoktriene B4; IL-8-interleukin 8; SLPI=secretory leukoprotease inhibitor. | ||||
| *p<0.05, **p<0.001, ***p=0.008 compared with presentation (Wilcoxon signed rank test). | ||||
| †p<0.05, ††p ⩽ 0.006, ‡2p<0.05 compared with “eradicated” group (Mann-Whitney U test). | ||||
| There was insufficient volume to measure SLPI in 6 samples, albumin in 5 samples, and NE, LTB4 and IL-8 in 4 samples. | ||||
| MPO (units/ml) | 0.99 (0.45–1.92) | 0.23** (0.12–0.43) | 1.17 (0.42–2.18) | 0.44†† (0.20–2.94) |
| NE (nM) | 8.37 (0.86–12.95) | 0.00* (0.00–8.09) | 14.96 (1.42–136.48) | 10.98*† (0.00–39.01) |
| LTB4 (nM) | 11.0 (5.00–21.24) | 2.87** (1.87–5.85) | 7.87 (5.15–25.87) | 9.14†† (4.66–30.01) |
| IL-8 (nM) | 5.29 (2.45–12.88) | 4.29 (2.19–6.2) | 6.07 (3.96–14.23) | 6.36 (1.93–12.36) |
| SLPI (μM) | 2.01 (0.57–2.79) | 5.45** (3.53–7.85) | 1.26 (0.41–3.11) | 3.65*† (1.35–4.76) |
| Albumin ratio (%) | 1.25 (0.67–3.02) | 0.47* (0.35–1.35) | 3.09‡ (1.24–4.73) | 0.86** (0.37–1.34) |
| Pathogen load (cfu/ml) | 2.2×108 (1.2×107−7.3×108) | 6.5×108 (5.5×107−2.6×109) | 6.4×107*** (5×106−9.5×108) | |