Concentrations of neutrophils (in BAL fluid), cytokines (in BAL fluid and serum in pg/ml), and CRP (in serum in mg/dl) in relation to hospital mortality
| Day 1 | Day 4 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| BAL fluid | Serum | Serum | |||||||
| Survivors(n = 77) | Non-survivors(n = 35) | p | Survivors(n = 77) | Non-survivors(n = 35) | p | Survivors(n = 77) | Non-survivors(n = 24) | p | |
| Data are presented as median (25–75th interquartile) or mean (SD). Neutrophil count is expressed as ×109 cells/l. | |||||||||
| Neutrophils | 1.85 (1.7) | 2.14 (1.4) | 0.003 | 6.9 (5.4) | 7.4 (6.1) | NS | – | – | – |
| Neutrophil (%) | 6 (1–30) | 21 (7–43) | 0.024 | – | – | – | – | – | – |
| TNF-α | 5 (1–27) | 11 (5–29) | 0.05 | 56 (36–102) | 72 (35–174) | NS | 52 (29–82) | 37 (16–67) | NS |
| IL-1β | 30 (9–57) | 28 (7–59) | NS | 1 (1–6) | 3 (1–40) | 0.05 | 1 (1–6) | 1 (1–42) | NS |
| IL-6 | 67 (12–288) | 210 (54–1121) | 0.024 | 78 (36–299) | 322 (140–905) | 0.001 | 42 (10–153) | 212 (20–763) | 0.05 |
| IL-8 | 73 (31–299) | 204 (46–874) | 0.05 | 44 (18–116) | 108 (76–275) | 0.006 | 38 (16–138) | 27 (8–97) | NS |
| IL-10 | 1 (1–11) | 3 (1–13) | NS | 22 (6–77) | 63 (20–115) | 0.03 | 16 (6–55) | 12 (1–97) | NS |
| CRP | – | – | – | 11.9 (4.7–20) | 16.3 (14.3–21.5) | NS | 5.5 (1.3–16.3) | 15.17 (12.3–18.2) | 0.024 |