Analysis to determine which parameters are associated with respiratory insufficiency as assessed by FEV1 <50% of predicted value
| Variable | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| OR (95% CI) | p value | OR (95% CI) | p value | |
| All quantitative variables were dichotomised according to the median. Fisher’s exact test was used for univariate analysis and a logistic regression was performed for multivariate analysis. | ||||
| OR, odds ratio; CI, confidence interval; BMI, body mass index. | ||||
| Severe genotype | 2.3 (0.8 to 6.7) | 0.14 | ||
| BMI <20 | 3.1 (1.1 to 8.3) | 0.04 | ||
| Pancreatic insufficiency | 3.3 (0.8 to 13.4) | 0.09 | ||
| P aeruginosa colonisation | 11.4 (2.1 to 62.7) | <0.001 | 13.8 (2.8 to 68.6) | 0.001 |
| Basal nasal PD ⩽−47 mV | 3.6 (1.3 to 9.9) | 0.01 | ||
| Δamil ⩾29 mV | 3.1 (1.1 to 8.3) | 0.04 | 3.7 (1.3 to 11.0) | 0.02 |
| ΔCl−/amil >−5 mV | 1.1 (0.4 to 2.8) | 0.8 | ||
| Δiso/Cl− >2 mV | 0.8 (0.3 to 2.0) | 0.6 | ||