Haemodynamic values before and after inhalation therapy
| Oxygen alone (n= 17) | Oxygen + NO (n= 15) | ||||
|---|---|---|---|---|---|
| Baseline | 3 months | Baseline | 3 months | p value | |
| Values are mean (SD). PAPm=mean pulmonary artery pressure; PAPs=systolic pulmonary artery pressure; PAPd=diastolic pulmonary artery pressure; PVR=pulmonary vascular resistance; PVRI=pulmonary vascular resistance index; HR=heart rate; CO=cardiac output; CI=cardiac index; PCWP=pulmonary capillary wedge pressure; APm=mean arterial pressure; APs=systolic arterial pressure; APd=diastolic arterial pressure. | |||||
| PAPm (mm Hg) | 24.6 (5.7) | 25.2 (6.5) | 27.6 (4.4) | 20.6 (4.9) | <0.001 |
| PAPs (mm Hg) | 33.8 (7.8) | 35.2 (8.6) | 40.1 (7.6) | 30.7 (6.3) | 0.003 |
| PAPd (mm Hg) | 17.8 (4.6) | 17.5 (5.6) | 20.1 (3.7) | 14.4 (4.6) | 0.045 |
| PVR (dyne•s−1•cm−5) | 259.5 (101.7) | 264.0 (109.2) | 276.9 (96.6) | 173.1 (87.9) | 0.001 |
| PVRI (dyne•s−1•cm−5•m−2) | 519.7 (209.5) | 552.3 (238.1) | 569.7 (208.1) | 351.3 (159.9) | <0.001 |
| HR (beats/min) | 78.1 (14.6) | 78.9 (11.9) | 78.9 (14.6) | 80.0 (15.0) | 0.889 |
| CO (l/min) | 5.5 (1.3) | 5.3 (1.3) | 5.6 (1.3) | 6.1 (1.0) | 0.025 |
| CI (l/min/m2) | 2.7 (0.5) | 2.7 (0.6) | 2.7 (0.6) | 3.0 (0.4) | 0.138 |
| PCWP (mm Hg) | 9.6 (2.9) | 9.4 (2.6) | 10.4 (3.3) | 8.4 (2.8) | 0.168 |
| APm (mm Hg) | 92.1 (16.2) | 90.6 (14.2) | 94.3 (13.2) | 94.9 (9.2) | 0.308 |
| APs (mm Hg) | 138.6 (30.1) | 131.3 (20.4) | 150.9 (25.8) | 141.1 (15.5) | 0.234 |
| APd (mm Hg) | 68.1 (11.6) | 67.9 (10.8) | 69.7 (11.0) | 72.8 (10.2) | 0.222 |