Comparison of epithelial immunostaining for ErbB receptors, mucins and PAS in smokers v non-smokers
| Epithelial marker | Non-smokers(n = 10) | Smokers(n = 51) |
|---|---|---|
| Data show median (range) percentage epithelial area immunostaining for ErbB receptor and mucin expression in bronchial biopsies of non-smokers and smokers. The bottom two lines of the table show the percentage of total epithelial cell numbers that were positive for MUC5AC and PAS. Data were analysed using the Mann-Whitney test. | ||
| *p<0.05; †p<0.01; ‡p<0.001. | ||
| EGFR | 2.8 (0.8–7.0) | 5.8 (0.3–22.3)* |
| ErbB2 | 1.3 (0–5.4) | 2.5 (0.1–9) |
| ErbB3 | 5.5 (1.0–19.0) | 14.7 (4–37.3)‡ |
| ErbB4 | 0.2 (0.03–1.9) | 0.7 (0–2.3) |
| MUC2 | 0.1 (0–1.1) | 0.7 (0–7.6) |
| MUC5B | 1.2 (0–8.1) | 0.9 (0–13.4) |
| MUC5AC | 3.3 (1.1–11.7) | 24.7 (3.5–49.3)‡ |
| MUC 5AC (% +ve cells) | 7.7 (0.4–21.4) | 32.5(0.4–59.6)‡ |
| PAS (% +ve cells) | 13.9 (0.5–19.2) | 26.8 (0–64.1)† |