Clinical characteristics of patients with and without emphysema
| Severe emphysema without α1-AT deficiency (SE+)(n = 10) | Severe emphysema with α1-AT deficiency (SE−)(n = 5) | Mild emphysema(ME)(n = 8) | Non-emphysema smokers (NE-S)(n = 9) | Non-emphysema non-smokers (NE-NS)(n = 11) | Between group differences | |
|---|---|---|---|---|---|---|
| *p<0.01 v SE+; †p<0.01 v ME; ‡p<0.05 v NE-S; §p<0.05 v ME (Mann-Whitney U test). | ||||||
| α1-AT, α1-antitrypsin; NS, non-significant; NA, not applicable. | ||||||
| Age (years) | 62.4 (7.5) | 58.4 (10.1) | 53.7 (11.0) | 57.0 (11.2) | 54.7 (19) | NS |
| Sex ratio (F/M) | 1/9 | 2/3 | 0/8 | 0/9 | 2/9 | NS |
| Smoking (pack years) | 49.0 (14.8) | 19.0 (6.5)*† | 49.3 (30.3) | 35.0 (14.9) | 0 | p<0.001 |
| Time since smoking cessation (years) | 7.0 (7.1)§ | 13.4 (8.6)†‡ | 1.0 (2.6) | 3.2 (6.7) | NA | p<0.001 |
| Active smokers/ex-smokers | 1/9 | 0/5 | 6/2 | 7/2 | NA | p<0.001 |