Inhibition by resveratrol of basal or stimulated cytokine release from alveolar macrophages
| Stimulus | Cytokine | Smokers | COPD |
|---|---|---|---|
| COPD=chronic obstructive pulmonary disease; CSM=cigarette smoke medium; IL=interleukin; GM-CSF=granulocyte macrophage-colony stimulating factor. | |||
| Values are mean (SE) IC50 values expressed as –log [resveratrol] (M) (n=15 per group). | |||
| Basal | IL-8 | 7.4 (0.4) | 6.9 (0.4) |
| GM-CSF | 7.0 (0.1) | 6.8 (0.1) | |
| IL-1β | IL-8 | 6.7 (0.1) | 6.2 (0.4) |
| GM-CSF | 6.9 (0.2) | 6.9 (0.3) | |
| CSM | IL-8 | 6.4 (0.3) | 7.4 (1.2) |
| GM-CSF | 7.1 (0.3) | 6.7 (0.2) | |