Prevalence of asthma related symptoms during the last 12 months, bronchial hyperresponsiveness, current asthma and skin prick test at age 8 (univariate analysis)
| Control | Prophylactic | OR (95% CI) | p value | |
|---|---|---|---|---|
| Values are n (%). | ||||
| BHR=bronchial hyperresponsiveness; OR=odds ratio; 95% CI=95% confidence interval. | ||||
| *As a yes response to ISAAC questions: have you had wheezing or whistling, nocturnal cough or exercise induced wheeze in the last 12 months. | ||||
| †Current asthma: current wheeze plus bronchial hyperresponsiveness (PC20 <8 mg/ml). | ||||
| ‡Skin test positive to either D pteronyssius or D farinae. | ||||
| §There were no skin test positive reactions to egg or fish in either group. ¶Geometric means (SD), means difference and 95% CI are given. | ||||
| Symptoms | N=62 | N=58 | ||
| Current wheeze* | 17 (27.4) | 8 (13.8) | 0.42 (0.17 to 1.08) | 0.08 |
| Nocturnal cough* | 20 (32.3) | 8 (13.8) | 0.34 (0.13 to 0.84) | 0.02 |
| Exercise induced wheeze* | 11 (17.7) | 6 (10.3) | 0.54 (0.18 to 1.56) | 0.30 |
| BHR | n=58 | n=52 | ||
| PC20 <8mg/ml | 25 (43.1) | 17 (32.7) | 0.64 (0.29 to 1.40) | 0.33 |
| Current asthma† | 9 (15.5) | 5 (9.6) | 0.58 (0.18 to 1.86) | 0.40 |
| Skin test positive | n=62 | n=55 | ||
| House dust mite‡ | 19 (30.7) | 6 (10.9) | 0.28 (0.10 to 0.76) | 0.01 |
| Grass pollen | 14 (22.6) | 10 (18.2) | 0.76 (0.31 to 1.89) | 0.65 |
| Tree pollen | 7 (11.3) | 1 (1.8) | 0.15 (0.02 to 1.22) | 0.07 |
| Cat | 10 (16.1) | 4 (7.3) | 0.41 (0.12 to 1.38) | 0.16 |
| Any aeroallergens | 28 (45.2) | 11 (20.0) | 0.30 (0.13 to 0.70) | 0.006 |
| Cows’ milk | 4 (6.5) | 0 | – | 0.12 |
| Peanut | 1 (1.6) | 0 | – | 1.0 |
| Any food allergens§ | 5 (8.1) | 0 | – | 0.06 |
| Any allergen (atopy) | 29 (46.8) | 11 (20.0) | 0.28 (0.12 to 0.65) | 0.003 |
| IgE | n=60 | n=53 | ||
| Inhalant screen positive | 22 (36.7) | 14 (26.4) | 0.62 (0.28 to 1.39) | 0.31 |
| Total IgE¶ | 91.69 (5.4) | 103.60 (5.5) | 1.13 (0.68 to 2.14) | 0.71 |