Assessment of inhibitory effects of different concentrations of cilomilast on mediators released by bronchial epithelial cells and sputum cells isolated from patients with COPD
| Bronchial epithelial cells | Sputum cells | |||||||
|---|---|---|---|---|---|---|---|---|
| Baseline | Cilomilast 0.1 μM | Cilomilast 1 μM | Cilomilast 10 μM | Baseline | Cilomilast 0.1 μM | Cilomilast 1 μM | Cilomilast 10 μM | |
| Results are expressed as median and 25–75th percentiles of three consecutive experiments. | ||||||||
| NA=not available because of undetectable levels of GM-CSF. | ||||||||
| TNF-α | 166 (165.2–201.2) | 150 (138.7–161.2) | 125.7 (111.3–131.9) | 155 (147–164.7) | 1742 (1476.5–1811) | 1523 (1205.7–1529.7) | 1020 (756.7–1155) | 1652 (1350.5–1652.7) |
| GM-CSF | NA | NA | NA | NA | 774 (686.2–831.7) | 569 (532.2–707.7) | 350 (233–548) | 652 (575.5–748) |