Table 5

Comparison of baseline and post-intervention scores of inflammatory markers in the epithelium and lamina propria of biopsy specimens taken from the central airways of patients with COPD, treated with either fluticasone propionate or placebo

EpitheliumLamina propria
Fluticasone propionatePlaceboFluticasone propionatePlacebo
MarkerBaselinePost-interventionBaselinePost-interventionBaselinePost-interventionBaselinePost-intervention
Data are expressed as median (range) ratios of immunostained areas and field measurement which consisted of the total area of either the epithelium or the lamina propria. Statistical analysis by paired Wilcoxon test after log transformation.
CD30.57 (0.10–4.52)0.28 (0.10–1.54)0.79 (0.35–2.23)0.45 (0.15–3.25)0.23 (0.04–5.71)0.20 (0.03–1.58)0.50 (0.20–1.40)0.31 (0.02–1.97)
CD41.03 (0.14–4.00)0.70 (0.40–2.03)1.11 (0.19–1.79)1.19 (0.70–2.17)0.68 (0.07–5.61)0.54 (0.18–1.02)0.80 (0.14–9.0)0.58 (0.47–1.48)
CD80.09 (0.05–0.60)0.09 (0.01–0.12)0.07 (0.03–0.26)0.07 (0.03–0.23)0.06 (0.03–0.42)0.03 (0.01–0.07)0.035 (0.03–0.16)0.02 (0.01–0.10)
CD250.16 (0.07–3.28)0.20 (0.03–0.31)0.27 (0.03–1.28)0.15 (0.00–1.79)0.17 (0.05–2.39)0.15 (0.02–0.51)0.13 (0.03–0.47)0.06 (0.00–0.46)
MBP0.06 (0.01–1.22)0.03 (0.01–0.25)0.20 (0.03–5.27)0.15 (0.00–1.05)0.29 (0.05–2.30)0.08 (0.01–0.64)0.46 (0.03–4.46)1.87 (0.00–6.45)
EG20.16 (0.01–0.45)0.06 (0.02–0.31)0.08 (0.03–1.79)0.07 (0.01–0.47)0.22 (0.13–0.68)0.28 (0.01–1.01)0.28 (0.03–2.5)0.72 (0.01–4.69)
CD153.31 (1.52–17.4)2.12 (0.08–8.68)4.32 (0.15–14.6)1.64 (0.53–27.70)0.40 (0.19–4.73)0.90 (0.19–3.73)0.68 (0.14–3.95)0.73 (0.15–3.98)
CD681.42 (0.24–11.4)0.81 (0.23–2.64)1.64 (0.39–9.86)1.19 (0.37–5.12)1.77 (0.44–20.1)0.98 (0.26–2.77)2.67 (0.52–4.35)1.76 (0.58–5.64)
CD1a0.14 (0.04–0.45)0.13 (0.05–0.29)0.10 (0.05–0.30)0.10 (0.01–0.19)0.16 (0.04–0.35)0.14 (0.04–0.59)0.12 (0.05–0.31)0.11 (0.02–0.21)
Tryptase0.10 (0.03–0.63)0.02 (0.00–0.18)0.18 (0.03–0.61)0.10 (0.02–0.59)0.67 (0.19–3.26)0.44 (0.02–0.74)1.95 (0.12–4.03)0.91 (0.01–3.97)