Table 4

Transmission disequilibrium test (TDT) analyses

Variables	No of genotyped offspring	Allele	Observed	Expected	p value
CRF asthma
−444	336	A	111	120.5	0.221
		C	130	120.5
−1072	313	G	46	43	0.518
		A	40	43
Atopy + CRF
−444	314	A	104	110.5	0.382
		C	117	110.5
−1072	292	G	45	40	0.264
		A	35	40
SPT positive + CRF
−444	273	A	99	100.5	0.832
		C	102	100.5
−1072	251	G	35	35	1.000
		A	35	35
Total IgE + CRF
−444	301	A	101	107	0.412
		C	113	107
−1072	279	G	41	38	0.491
		A	35	38
Specific IgE + CRF
−444	289	A	101	104	0.677
		C	107	104
−1072	267	G	38	37.5	0.908
		A	37	37.5
PC₂₀ ⩽16 mg/ml + CRF
−444	291	A	100	107	0.339
		C	114	107
−1072	273	G	42	42	1.000
		A	42	42
PC₂₀ <4 mg/ml + CRF
−444	241	A	79	91.5	0.065
		C	104	91.5
−1072	225	G	38	35.5	0.553
		A	33	35.5
CRF=Complete Report Form; SPT=skin prick tests; PC₂₀=concentration of methacholine needed to provoke a fall in forced expiratory volume in 1 second of 20% or more.