| Symptom severity | ||||||
|---|---|---|---|---|---|---|
| Screening (week 0) | Baseline (week 4) | Endpoint (week 16 or time of withdrawal) | ||||
| A* | F** | A | F | A | F | |
| *A=adjustable; **F=fixed. | ||||||
| Number of patients | 775 | 766 | 775 | 766 | 754 | 737 |
| Severity status (%) | ||||||
| Severe persistent | 6 | 6 | 4 | 4 | 4 | 4 |
| Moderate persistent | 45 | 47 | 34 | 33 | 25 | 25 |
| Mild persistent | 31 | 29 | 32 | 31 | 31 | 30 |
| Mild intermittent | 18 | 19 | 30 | 33 | 40 | 40 |