Influence of previous steroid use on the time to achieve asthma control, time to first mild or severe asthma exacerbation, and frequency of mild and severe exacerbations
| Previous inhaled steroid users | Patients starting inhaled steroids | ||||
|---|---|---|---|---|---|
| Treatment* | BUD+EF | BUD+PL | BUD+EF | BUD+PL | p value |
| *BUD=800 μg daily during part I and 400 μg daily during part II. | |||||
| p value for comparison of previous inhaled steroid users with patients starting regular treatment with inhaled steroids, adjusted for treatment. | |||||
| Part I (n) | 223 | 223 | 109 | 108 | |
| % controlled by 4 weeks | 52 | 41 | 53 | 42 | 0.8 |
| Part II (n) | 164 | 177 | 86 | 78 | |
| % experiencing a mild exacerbation by 6 months | 35 | 46 | 35 | 47 | 0.9 |
| Mild exacerbation rate (no/patient/6 months) | 7.15 | 10.40 | 7.33 | 10.66 | 0.9 |
| % experiencing a severe exacerbation by 6 months | 7 | 11 | 8 | 12 | 0.7 |
| Severe exacerbation rate (no/patient/6 months) | 0.10 | 0.15 | 0.12 | 0.18 | 0.4 |