Previous inhaled steroid users | Patients starting inhaled steroids | ||||
---|---|---|---|---|---|
Treatment* | BUD+EF | BUD+PL | BUD+EF | BUD+PL | p value |
*BUD=800 μg daily during part I and 400 μg daily during part II. | |||||
p value for comparison of previous inhaled steroid users with patients starting regular treatment with inhaled steroids, adjusted for treatment. | |||||
Part I (n) | 223 | 223 | 109 | 108 | |
% controlled by 4 weeks | 52 | 41 | 53 | 42 | 0.8 |
Part II (n) | 164 | 177 | 86 | 78 | |
% experiencing a mild exacerbation by 6 months | 35 | 46 | 35 | 47 | 0.9 |
Mild exacerbation rate (no/patient/6 months) | 7.15 | 10.40 | 7.33 | 10.66 | 0.9 |
% experiencing a severe exacerbation by 6 months | 7 | 11 | 8 | 12 | 0.7 |
Severe exacerbation rate (no/patient/6 months) | 0.10 | 0.15 | 0.12 | 0.18 | 0.4 |