Table 2

Mean (SD) run in response and mean change in daily diary card assessments of daytime and night time reliever inhaler use, symptom severity, and nocturnal disturbance. Minimum and maximum values are shown in square brackets

	Part I				Part II
	BUD800+EF		BUD800+PL		BUD400+EF		BUD400+PL
	Run in	Change to 4 weeks	Run in	Change to 4 weeks	Baseline (week 4)	Change to 6 months	Baseline (week 4)	Change to 6 months
p=0.0001 within treatment change from baseline; †p<0.01 within treatment change from baseline; ‡p=0.0001 between treatment change from baseline; §=p<0.001 between treatment change from baseline; ¶p<0.01 between treatment change from baseline; *p<0.05 between treatment change from baseline.
Relief inhaler use:
Inhalations/day	2.09 (1.42)	−1.18 (1.45)*	2.01 (1.48)	−0.85 (1.26)*§	0.71 (0.86)	−0.17 (0.82)*	0.74 (0.88)	+0.20 (1.08)‡
	[0, 8.7]	[−8.7, 4.6]	[0, 9.0]	[−7.1, 2.6]	[0, 4.3]	[−3.0, 3.0]	[0, 4.7]	[−2.9, 5.7]
Inhalations/night	0.69 (0.75)	−0.38 (0.73)*	0.75 (0.86)	−0.26 (0.75)* **	0.23 (0.45)	−0.001 (0.37)	0.23 (0.47)	+0.18 (0.51)*‡
	[0, 3.1]	[−2.6, 2.7]	[0, 4.1]	[−3.4, 2.0]	[0, 2.3]	[−1.6, 1.1]	[0, 3.9]	[−1.0, 3.1]
Symptom score:
Daytime	1.23 (0.53)	−0.50 (0.60)*	1.20 (0.56)	−0.35 (0.61)*¶	0.64 (0.57)	−0.16 (0.54)*	0.64 (0.60)	+0.01 (0.54)‡
	[0, 3.0]	[−2.1, 1.4]	[0, 3.0]	[−2.4, 1.4]	[0, 2.7]	[−2.0, 2.0]	[0, 3.0]	[−1.4, 1.7]
Night time	0.91 (0.66)	−0.38 (0.66)*	0.90 (0.65)	−0.28 (0.65)*	0.39 (0.49)	−0.05 (0.43)†	0.46 (0.58)	+0.03 (0.49)¶
	[0, 3.0]	[−2.4, 1.4]	[0, 3.0]	[−2.1, 2.3]	[0, 2.6]	[−1.6, 1.6]	[0, 3.0]	[−1.4, 1.9]
Sleep disturbance:
Nights/week	1.70 (2.26)	−1.01 (2.15)*	1.59 (2.14)	−0.58 (2.16)* **	0.29 (1.06)	−0.01 (1.09)	0.47 (1.39)	+0.05 (1.35)
	[0, 7]	[−7, 6]	[0, 7]	[−7, 7]	[0, 7]	[−7, 7]	[0, 7]	[−7, 7]