6 ml/kg v 12 ml/kg tidal volume strategies and surfactant protein levels
| Surfactant protein level | 6 ml/kg | 12 ml/kg | Total | p values* | ||||
|---|---|---|---|---|---|---|---|---|
| N | Median (IQR) | N | Median (IQR) | N | Median (IQR) | Change over time | Ventilator group | |
| For each tidal volume group and the total sample, the number of subjects (n) and the median (25–75th interquartile range) are presented. | ||||||||
| *ANCOVA for model: surfactant protein level at day 3=ventilator group + surfactant protein level at day 0. | ||||||||
| SP-A=surfactant protein A; SP-D=surfactant protein D. | ||||||||
| SP-A (ng/ml) | <0.0001 | 0.97 | ||||||
| Day 0 | 277 | 30 (14–61) | 288 | 30 (14–68) | 565 | 30 (14–64) | ||
| Day 3 | 244 | 50 (24–92) | 251 | 53 (25–91) | 495 | 52 (25–92) | ||
| Difference (day 3–day 0) | 240 | 12 (0–36) | 248 | 10 (−2–37) | 488 | 11 (−1–37) | ||
| SP-D (ng/ml) | <0.0001 | 0.0006 | ||||||
| Day 0 | 277 | 84 (40–162) | 288 | 77 (37–172) | 565 | 82 (38–166) | ||
| Day 3 | 243 | 143 (69–243) | 250 | 172 (83–337) | 493 | 152 (77–283) | ||
| Difference (day 3–day 0) | 239 | 142 (71–240) | 247 | 170 (81–334) | 486 | 151 (76–281) | ||