Mean (SE) β2 adrenoceptor levels of receptor expression (Bmax), receptor affinity (Kd), and the ability of isoprenaline to stimulate cyclic AMP formation (Emax)
| Loci | Genotype | Bmax (fmol/mg) | p value | Kd (pmol) | p value | Emax (% above basal) | p value |
|---|---|---|---|---|---|---|---|
| The data were averaged by genotype groups to test for a particular genotype association with a clinical phenotype (ANOVA). Data were derived from a Dundee population (n = 58) and a Dutch population (n=38). *p<0.05. | |||||||
| –367 T/C | T/T | 2.75 (0.32) | 0.27 | 21.5 (2.26) | 0.71 | 289 (27.7) | 0.01* |
| T/C | 2.17 (0.17) | 19.5 (1.80) | 452 (57.3) | ||||
| C/C | 2.43 (0.22) | 21.3 (1.69) | 327 (39.3) | ||||
| –47 T/C | T/T | 2.78 (0.32) | 0.27 | 20.5 (2.36) | 0.98 | 305 (28.4) | 0.17 |
| C/T | 2.38 (0.19) | 20.9 (1.89) | 409 (57.8) | ||||
| C/C | 2.27 (0.18) | 20.4 (1.54) | 331 (37.5) | ||||
| Arg16→Gly | Arg16 | 2.55 (0.22) | 0.73 | 25.2 (3.24) | 0.11 | 290 (71.6) | 0.68 |
| HET | 2.54 (0.17) | 21.3 (1.40) | 363 (40.2) | ||||
| Gly16 | 2.33 (0.24) | 18.6 (1.65) | 339 (31.5) | ||||
| Gln27→Glu | Gln27 | 2.48 (0.23) | 0.26 | 22.4 (1.96) | 0.54 | 329 (31.3) | 0.89 |
| HET | 2.22 (0.17) | 19.5 (1.73) | 353 (31.9) | ||||
| Glu27 | 2.73 (0.29) | 20.5 (1.88) | 352 (30.9) | ||||