Haplotype frequencies determined from the data in table 3 using the Estimated Haplotype program to estimate the haplotype combinations of the double, triple and quadruple heterozygous genotypes, both with and without association
| Haplotype | Frequency | ||||
|---|---|---|---|---|---|
| –367 (T/C) | –47 (C/T) | Arg16→Gly | Gln27→Glu | With association | Without association |
| Logn (l) χ2 statistic = 249.08, df = 11 (p = 0.00008) suggests strong linkage disequilibrium across these loci. Four haplotypes did not occur with association. | |||||
| C | C (Arg19) | Gly16 | Glu27 | 0.32 | 0.06 |
| T | T (Cys19) | Arg16 | Gln27 | 0.26 | 0.05 |
| T | T (Cys19) | Gly16 | Gln27 | 0.16 | 0.12 |
| T | T (Cys19) | Gly16 | Glu27 | 0.13 | 0.13 |
| T | C (Arg19) | Gly16 | Glu27 | 0.036 | 0.091 |
| C | C (Arg19) | Arg16 | Gln27 | 0.029 | 0.023 |
| C | T (Cys19) | Gly16 | Glu27 | 0.022 | 0.079 |
| T | C (Arg19) | Gly16 | Gln27 | 0.017 | 0.089 |
| T | T (Cys19) | Arg16 | Glu27 | 0.007 | 0.058 |
| T | C (Arg19) | Arg16 | Gln27 | 0.007 | 0.038 |
| C | T (Cys19) | Gly16 | Gln27 | 0.007 | 0.075 |
| C | C (Arg19) | Gly16 | Gln27 | 0.00006 | 0.052 |