The three determinants of ventilation and common pathophysiological conditions associated with failure to wean
Sedation, analgesia or anaesthesia
Coma
Raised intracranial pressure
Hypercapnia
Hypophosphataemia
Disuse atrophy
Sepsis
Polyneuropathy/myopathy
Hyperinflation
Left ventricular failure
Bronchospasm
Lung fibrosis