Odds ratios (95% CI) for wheezing at 30–42 months associated with paracetamol and aspirin use (n=9400)
| No. (wheeze/total) | Unadjusted OR (95% CI) | Adjusted* OR (95% CI) | |
|---|---|---|---|
| *Adjusted for factors in table 1. | |||
| †Could not be estimated. | |||
| Paracetamol use in pregnancy: | |||
| 0–20 weeks | |||
| Never | 516/4265 | 1.00 | 1.00 |
| Some days | 689/4836 | 1.21 (1.07 to 1.36) | 1.07 (0.94 to 1.22) |
| Most days/daily | 21/111 | 1.70 (1.04 to 2.75) | 1.19 (0.72 to 1.97) |
| Unknown | 32/188 | 1.49 (1.01 to 2.20) | 1.47 (0.88 to 2.47) |
| 20–32 weeks | |||
| Never | 608/5134 | 1.00 | 1.00 |
| Some days | 561/3725 | 1.34 (1.18 to 1.52) | 1.12 (0.98 to 1.28) |
| Most days/daily | 26/88 | 3.17 (1.99 to 5.05) | 2.10 (1.30 to 3.41) |
| Unknown | 71/453 | 1.40 (1.08 to 1.83) | 0.58 (0.23 to 1.47) |
| Aspirin use in pregnancy: | |||
| 0–20 weeks | |||
| Never | 1150/8778 | 1.00 | 1.00 |
| Some days | 66/385 | 1.37 (1.05 to 1.80) | 1.26 (0.95 to 1.68) |
| Most days/daily | 12/65 | 1.50 (0.80 to 2.82) | 1.05 (0.51 to 2.16) |
| Unknown | 30/172 | 1.40 (0.94 to 2.09) | 1.59 (0.90 to 2.82) |
| 20–32 weeks | |||
| Never | 1145/8664 | 1.00 | 1.00 |
| Some days | 34/220 | 1.20 (0.83 to 1.74) | 1.03 (0.71 to 1.51) |
| Most days/daily | 8/63 | 0.96 (0.45 to 2.01) | 0.64 (0.28 to 1.48) |
| Unknown | 71/453 | 1.22 (0.94 to 1.58) | 0.55 (0.22 to 1.37) |
| Paracetamol use in infancy: | |||
| 0–6 months | |||
| Never | 130/1245 | 1.00 | 1.00 |
| Once | 210/1860 | 1.09 (0.87 to 1.38) | 1.06 (0.84 to 1.34) |
| More than once | 916/6277 | 1.47 (1.21 to 1.78) | 1.29 (1.05 to 1.57) |
| Unknown | 2/18 | 1.07 (0.24 to 4.72) | –† |