Table 2

Odds ratios for the risk factors for the presence of wheeze in the past year with and without an asthma diagnosis with adjustment for IgE levels

		Wheeze in the past year without a diagnosis of asthma			Wheeze in the past year and diagnosis of asthma
	No	Adjusted* OR	95% CI	p value**	Adjusted* OR	95% CI	p value**
*Adjustment is for all variables listed.
**Significance levels are based on a test for heterogeneity except for age and social class which are based on tests for trend using ordered categories.
*** I=professional; II=managerial; IIInm=clerical; IIIm=skilled manual; IV=semi-skilled manual; V=unskilled manual.
Sex
Female	13021	1	(reference)	0.001	1	(reference)	<0.001
Male	11929	1.16	1.07 to 1.25		0.63	0.57 to 0.69

Age
11–19	2385	1	(reference)	<0.001	1	(reference)	0.561
20–29	3371	1.10	0.90 to 1.35		0.91	0.75 to 1.09
30–39	4726	1.01	0.84 to 1.23		0.66	0.55 to 0.79
40–49	4399	1.31	1.08 to 1.58		0.65	0.53 to 0.78
50–59	3529	1.53	1.26 to 1.86		0.74	0.61 to 0.91
60–69	3209	1.87	1.54 to 2.27		0.88	0.72 to 1.08
70–79	2366	2.16	1.76 to 2.65		0.96	0.77 to 1.19
80–89	885	2.25	1.74 to 2.90		0.83	0.60 to 1.14
90+	80	2.87	1.55 to 5.30		0.15	0.02 to 1.08

Social class***
I	1646	1	(reference)	<0.001	1	(reference)	<0.001
II	7302	1.16	0.96 to 1.42		0.94	0.77 to 1.16
IIInm	3246	1.22	0.99 to 1.51		0.93	0.74 to 1.17
IIIm	7095	1.54	1.27 to 1.87		1.12	0.91 to 1.37
IV	3299	1.42	1.16 to 1.75		1.12	0.89 to 1.40
V	1204	1.56	1.23 to 1.99		1.27	0.96 to 1.68

Urban/rural
Rural	5945	1	(reference)	0.002	1	(reference)	0.106
Urban	19005	1.17	1.06 to 1.29		1.10	0.98 to 1.24

Smoking
Never	6822	1	(reference)		1	(reference)
Ex	9894	1.61	1.45 to 1.79	<0.001	1.50	1.33 to 1.71	<0.001
Current	6240	3.41	3.09 to 3.76	<0.001	1.43	1.27 to 1.62	<0.001

Total IgE
0–3	2400	1	(reference)	<0.001	1	(reference)	<0.001
4–9	2907	1.05	0.88 to 1.27		1.03	0.77 to 1.37
10–31	6109	1.09	0.93 to 1.27		1.23	0.96 to 1.58
32–99	6501	1.12	0.96 to 1.31		1.80	1.42 to 2.29
100–315	4624	1.34	1.14 to 1.59		2.58	2.02 to 3.29
316–999	1850	1.50	1.23 to 1.84		3.30	2.54 to 4.31
1000+	559	1.28	0.94 to 1.75		3.93	2.85 to 5.41

HDM IgE
0–0.3	20004	1	(reference)	<0.001	1	(reference)	<0.001
0.4–10.0	3134	1.10	0.97 to 1.25		1.77	1.54 to 2.04
>10	1812	1.51	1.26 to 1.81		4.50	3.84 to 5.26