In the absence of other clinical explanations patients must have: |
(1) Recurrent oral ulceration (aphthous or herpetiform) observed by the physician or patient recurring at least three times in one 12 month period |
+ two of the following: |
(2) Recurrent genital ulceration |
(3) Eye lesions: |
• anterior uveitis; |
• posterior uveitis (cells in the vitreous observed by slit lamp examination); or |
• retinal vasculitis observed by an ophthalmologist. |
(4) Skin lesions: |
• erythema nodosum; |
• pseudofolliculitis; |
• papulopustular lesions or acneiform nodules in post-adolescent patients not on corticosteroids |
(5) Positive skin pathergy test read by a physician at 48 hours—that is, a 2 mm erythematous papule or pustule at the prick site 48 hours after the application of a sterile hypodermic 20–22 gauge needle which obliquely penetrated avascular antecubital skin to a depth of 5 mm. |