Comparisons of total and individual diary card scores for dyspnoea, sputum colour, and sputum volume for patients in the purulent group receiving 5 versus 10 days antibiotic treatment and those in the mucoid group receiving inhaled fluticasone versus placebo
| Presentation | Day 5 | End of treatment | Stable state | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 5 days | 10 days | FP | Placebo | 5 days | 10 days | FP | Placebo | 5 days | 10 days | FP | Placebo | 5 days | 10 days | FP | Placebo | ||||
| Total score | |||||||||||||||||||
| Mean (SE) | 20.5 (1.1) | 18.7 (1.4) | 16.1 (1.2) | 16.5 (1.6) | 13.9 (0.7) | 12.2 (1.2) | 14.7 (1.1) | 14.5 (1.1) | 12.0 (0.8) | 10.8 (1.0) | 12.5 (1.3) | 13.0 (1.1) | 13.1 (1.3) | 10.5 (1.6) | 14.7 (1.3) | 13.2 (1.2) | |||
| Mean difference (95% CI) | 1.9 (–1.6 to 5.4) | –0.4 (–4.6 to 3.7) | 1.6 (–1.2 to 4.4) | 0.2 (–3.0 to 3.5) | 1.2 (–1.4 to 3.8) | –0.5 (–4.4 to 3.4) | 2.6 (–1.5 to 6.7) | 1.5 (–2.2 to 5.3) | |||||||||||
| p value | 0.220 | 0.235 | 0.179 | 0.416 | 0.240 | 0.458 | 0.153 | 0.271 | |||||||||||
| Dyspnoea | |||||||||||||||||||
| Mean (SE) | 3.1 (0.2) | 2.7 (0.2) | 2.7 (0.2) | 3.0 (0.3) | 2.0 (0.1) | 2.1 (0.2) | 2.4 (0.2) | 2.3 (0.2) | 2.0 (0.1) | 1.8 (0.2) | 2.1 (0.2) | 2.2 (0.2) | 2.2 (0.2) | 1.7 (0.2) | 2.3 (0.2) | 2.1 (0.2) | |||
| Mean difference (95% CI) | 0.4 (–0.1 to 0.9) | –0.3 (–0.9 to 0.3) | –0.1 (–0.5 to 0.3) | 0.1 (–0.6 to 0.7) | 0.2 (–0.3 to 0.6) | –0.1 (–0.7 to 0.5) | 0.4 (–0.1 to 1.0) | 0.1 (–0.6 to 0.9) | |||||||||||
| p value | 0.069 | 0.207 | 0.384 | 0.464 | 0.296 | 0.369 | 0.108 | 0.420 | |||||||||||
| Colour | |||||||||||||||||||
| Mean (SE) | 3.5 (0.2) | 3.6 (0.2) | 1.8 (0.2) | 2.0 (0.3) | 2.3 (0.2) | 2.1 (0.3) | 1.9 (0.3) | 2.5 (0.3) | 1.8 (0.2) | 1.7 (0.3) | 1.8 (0.3) | 2.0 (0.3) | 1.9 (0.2) | 1.7 (0.3) | 1.8 (0.2) | 2.4 (0.2) | |||
| Mean difference (95% CI) | –0.1 (–0.7 to 0.5) | –0.2 (–0.9 to 0.4) | 0.2 (–0.6 to 1.0) | –0.6 (–1.4 to 0.3) | 0.1 (–0.6 to 0.8) | –0.2 (–1.3 to 0.8) | 0.2 (–0.5 to 0.9) | 0.3 (–1.2 to 0.1) | |||||||||||
| p value | 0.392 | 0.278 | 0.275 | 0.093 | 0.426 | 0.301 | 0.247 | 0.065 | |||||||||||
| Volume | |||||||||||||||||||
| Mean (SE) | 1.7 (0.1) | 1.6 (0.2) | 1.8 (0.2) | 1.5 (0.2) | 1.3 (0.1) | 1.0 (0.2) | 1.6 (0.1) | 1.3 (0.2) | 1.1 (0.1) | 0.8 (0.1) | 1.4 (0.2) | 1.1 (0.2) | 1.2 (0.1) | 0.9 (0.2) | 1.5 (0.2) | 1.3 (0.2) | |||
| Mean difference (95% CI) | 0.1 (–0.4 to 0.5) | 0.3 (–0.3 to 0.9) | 0.3 (–0.2 to 0.7) | 0.3 (–0.1 to 0.7) | 0.3 (–0.1 to 0.7) | 0.3 (–0.4 to 0.9) | 0.2 (–0.2 to 0.7) | 0.2 (–0.5 to 0.9) | |||||||||||
| p value | 0.426 | 0.168 | 0.098 | 0.104 | 0.094 | 0.179 | 0.176 | 0.300 | |||||||||||
5 days = 5 days antibiotic treatment; 10 days = 10 days antibiotic treatment; FP = inhaled fluticasone.