Table 3

Cytokine production by alveolar macrophages (AM), divided retrospectively according to subjects' development of lung disease after stem cell transplantation (SCT)

AM obtained before SCT (B1)AM obtained during post-SCT pancytopenia (B2)
CytokineNo post-SCT lung disease (n=22)Post-SCT lung disease (n=10)SignificanceNo post-SCT lung disease (n=19)Post-SCT lung disease (n=5)Significance
TNFα1.9 (1.0–4.6)7.9 (1.1–8.4) p = 0.01 3-150 1.9 (0.31–3.3)4.6 (2.2–9.0)p = 0.07
GM-CSF0.21 (0.07–0.79)5.2 (0.72–8.3) p = 0.006† 0.11 (0.06–0.32)1.2 (0.74–9.1) p = 0.013-154
IL-1β0.18 (0.07–0.91)0.95 (0.15–2.2)p = 0.060.18 (0.01–0.43)0.13 (0.06–1.4)p = 0.6
IL-60.10 (0.02–0.29)0.46 (0.13–1.23) p = 0.0493-152 0.07 (0.04–0.13)0.13 (0.06–2.1)p = 0.2
IL-8417 (204–533)460 (298–805)p = 0.3172 (90–334)355 (238–777)p = 0.2

  • Values are medians (interquartile range) in ng/106AM.

  • ↵3-150 Median difference 3.4 (95% confidence interval (CI) 0.08 to 7.0). † Median difference 4.4 (95% CI 0.47 to 7.5).

  • ↵3-152 Median difference 0.3 (95% CI 0.0002 to 0.92).

  • ↵3-154 Median difference 1.1 (95% CI 0.11 to 5.8).