Radiotherapy details
| Reference | Radiation dose (Gy/no of fractions (F)) | Mediastinum included (% patients) |
| Haffty (1988)8 | Continuous: median 59 Gy in 2 Gy fractions or Split: median 54 Gy in median 2.75 Gy fractions | 88% |
| Sandler (1990)10 | Median 60 Gy/30F/6 weeks | 90% |
| Ono (1991)11 | 60–70 Gy/30–35F split over 8–10 weeks | 32% |
| Kaskowitz (1993)12 | 40–79 Gy (median 63 Gy) | 89% |
| Slotman (1994)13 | 32 Gy/6F twice weekly, 40 Gy/10F split, 48 Gy/12F daily or 56 Gy/20F daily. | 71% |
| Gauden (1995)14 | 50 Gy/20F/4 weeks | 100% |
| Park (1995)15 | 60 Gy/30F | Not stated |
| Krol (1996)16 | 60 Gy/20F split over 7 weeks or 65 Gy/26F daily | 0% |
| Slotman (1996)17 | 48 Gy/12F daily | 0% |
| Morita (1997)18 | 55–74 Gy mostly in 2 Gy fractions | 44% |
| Jeremic (1997)19 | 69.6 Gy/58F treatment twice daily | Hilum included |
| Nguyen-Tan (1998)20 | 40 Gy/10F split—64 Gy/32F | Not stated |
| Sibley (1998)21 | 50–80 Gy in 1.2–3 Gy fractions; 15 patients treated twice daily | 73% |
| Hayakawa (1999)22 | 48–81 Gy in 2 Gy daily fractions | 28% |
| Salloum (1990)23 | 15–66 Gy (71% ⩾50 Gy; 25% split course) | Not stated |
| Rosenthal (1992)24 | 18–65 Gy (median 60 Gy) | 100% |
| Zhang (1989)25 | 55–70 Gy in 6–7 weeks | 100% |
| Schildge (1993)27 | 60 Gy/30F | Not stated |
| Graham (1995)28 | Median 60 Gy/30F daily (range 18–60 Gy) | 80% |
| Koukourakis (1995)29 | NTD 48–64 Gy in 2–4 Gy fractions over 3–10 weeks | 100% |
| Furuta (1996)30 | 60–80 Gy/6–8 weeks | 81% |
| Hayakawa (1996)31 | 60–74 Gy in 2 Gy fractions; 10 patients received 80–90 Gy | 85% |
| Saunders (1999),6 Bentzen (2000)7 | 60 Gy/30F daily or 54 Gy/36F/12 days (CHART) | 100% |
| Anderson (2000)34 | 45–55 Gy/15–16F daily | Not stated |
| Talton (1990)35 | 60 Gy/30F/6 weeks | 100% |
| Dosoretz (1992),36 (1993),37(1996)38 | 45–75 Gy in 1.8–2 Gy fractions | Most |
| Kupelian (1996)39 | Median 63 Gy | 72% |
NTD = nominal total dose.
Randomised trial shown in bold.