Cessation of action of inhaled budesonide on exhaled markers, lung function, and symptoms in patients with mild asthma
| Days | NO (ppb) | CO (ppm) | NO2−/NO3− (μM) | 8-iso (pg/ml) | FEV1 (% pred) | PEF (l/min) | Symptom score (units) |
|---|---|---|---|---|---|---|---|
| NO=nitric oxide; CO=carbon monoxide; NO2−=nitrite; NO3−=nitrate; S-NO=S-nitrosothiols; 8-iso=8-isoprostane; FEV1=forced expiratory volume in 1 second; PEF=peak expiratory flow. | |||||||
| Data are mean (95% CI). | |||||||
| *p<0.05, **p<0.01 v post-treatment (day 21) value. | |||||||
| Budesonide 400 μg/day | |||||||
| Last day of treatment (day 21) | 11.4 (8.5 to 14.3) | 2.4 (1.6 to 3.3) | 45 (26 to 54) | 7.2 (3.9 to 10.5) | 94 (84 to 105) | 449 (387 to 510) | 0.3 (–0.16 to 0.71) |
| No treatment (day 24) | 15.9** (12.6 to 19.1) | 2.82.2 to 3.5) | 51 (41 to 62) | 11.7 (2.1 to 21.3) | 95 (84 to 106) | 458 (401 to 515) | 0.5 (0.19 to 0.90) |
| (day 26) | 19.7** (16.6 to 22.7) | 3.5* (2.6 to 4.3) | 50 (35 to 65) | 10.4 (5.4 to 15.4) | 88 (77 to 100) | 437 (366 to 508) | 0.5 (–0.10 to 1.01) |
| (day 29) | 18.4** (14.6 to 22.2) | 3.1 (2.1 to 4.1) | 56* (51 to 61) | 9.9 (5.6 to 14.3) | 90 (81 to 100) | 451 (392 to 511) | 0.3 (–0.04 to 0.59) |
| Budesonide 100 μg/day | |||||||
| Last day of treatment (day 21) | 13.4 (10.7 to 16.2) | 2.8 (1.9 to 3.7) | 43 (15 to 70) | 10.7 (4.7 to 16.7) | 93 (86 to 101) | 502 (455 to 549) | 0.9 (–0.01 to 1.83) |
| No treatment (day 24) | 13.9 (10.4 to 17.4) | 3.6* (2.5 to 4.6) | 55 (48 to 63) | 10.4 (3.5 to 17.3) | 92 (84 to 101) | 520 (478 to 561) | 0.5 (–0.15 to 1.24) |
| (day 26) | 15.5 (11.8 to 19.2) | 3.4 (2.3 to 4.5) | 40 (22 to 59) | 8.2 (0.9 to 15.6) | 91 (84 to 98) | 516 (474 to 558) | 0.4 (–0.09 to 0.82) |
| (day 29) | 16.7 (11.9 to 21.5) | 3.7 (2.9 to 4.4) | 44 (21 to 66) | 9.7 (3.0 to 16.3) | 93 (88 to 98) | 507 (457 to 556) | 0.7 (0.05 to 1.41) |
| Placebo | |||||||
| Last day of treatment (day 21) | 15.9 (9.5 to 22.4) | 2.9 (1.6 to 4.2) | 53 (42 to 65) | 14.7 (8.5 to 20.8) | 88 (76 to 105) | 487 (361 to 613) | 0.02 (–0.03 to 0.06) |
| No treatment (day 24) | 14.9 (9.5 to 20.3) | 2.9 (1.4 to 4.4) | 40 (27 to 53) | 11.3 (7.3 to 15.4) | 92 (84 to 101) | 510 (305 to 715) | 0.02 (–0.03 to 0.06) |
| (day 26) | 15.2 (10.7 to 19.6) | 3.0 (1.7 to 4.4) | 38 (17 to 58) | 15.1 (7.2 to 23.0) | 91 (84 to 98) | 472 (347 to 597) | 0.5 (–0.79 to 1.79) |
| (day 29) | 16.6 (10.9 to 22.3) | 3.6 (2.6 to 4.5) | 45 (12 to 77) | 9.9 (2.9 to 16.8) | 93 (88 to 98) | 513 (381 to 646) | 0.3 (–0.52 to 1.19) |