Factors involved in susceptibility or resistance to tuberculosis and subject to genetically determined variation.
| Factor or gene | Function or mode of action |
| Natural resistance associated macrophage protein (NRAMP 1) | ?Regulation of phagosome cation levels |
| Mannose binding lectin protein | Entry of mycobacteria into cells |
| HLA-D | Antigen presentation |
| Vitamin D | Macrophage activation |
| Locus on chromosome 15 | Unknown |
| Locus on X chromosome | Unknown, may account for higher rates of tuberculosis in males |
| Haptoglobin | ?Regulator of lymphocyte function |
| Km1 immunoglobulin allotypes | ?Related to autoimmune tissue damage |
| Various cytokines | T cell maturation and patterns of immune reactivity |