Mean (SE) data with 95% confidence intervals (CI) of study subjects
| Parameter | WG | Sarcoidosis | p Value1-151 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Mean (SE) | 95% CI | Mean (SE) | 95% CI | ||||||
| Age (years) | 63 (4) | 54 to 71 | 44 (6) | 27 to 60 | <0.05 | ||||
| Disease duration (years) | 3.5 (1.1) | 0.9 to 6.1 | 0.8 (0.5) | 0.1 to 2.1 | NS | ||||
| Current DEI | 4.7 (0.4) | 3.5 to 5.8 | |||||||
| BVAS | 15.1 (1.4) | 8.8 to 12.2 | |||||||
| ESR (mm/h) | 48 (10) | 26 to 69 | 63 (14) | 28 to 97 | NS | ||||
| CRP (mg/l) | 20 (8) | 2 to 39 | 51 (16) | 12 to 89 | NS | ||||
| Leucocyte count (× 103/mm3) | 5.9 (0.4) | 4.9 to 6.9 | 6.0 (0.5) | 4.4 to 7.5 | NS | ||||
| Thrombocyte count (× 103/mm3) | 263 (21) | 224 to 300 | 451 (86) | 280 to 622 | <0.05 | ||||
| Creatinine (mg/l) | 15 (3) | 7 to 22 | 8 (1) | 6 to 9 | <0.05 | ||||
| CD4+/CD28– blood (%) | 13.4 (6.2)1-152 | 0.5 to 27.4 | 4.1 (2.5) | 1.8 to 10.2 | NS | ||||
| CD4+/CD28– BAL (%) | 65.6 (5.4)1-152 | 53.4 to 77.8 | 6.7 (2.2) | 1.4 to 12.2 | <0.001 | ||||
| CD8+/CD28– blood (%) | 42.9 (6.2)1-152 | 28.9 to 56.9 | 52.0 (9.4) | 29.1 to 74.9 | NS | ||||
| CD8+/CD28– BAL (%) | 76.3 (4.1)1-152 | 67.1 to 85.5 | 53.4 (7.3) | 35.5 to 68.2 | <0.05 | ||||
WG = Wegener's granulomatosis; DEI = disease extension index15; BVAS = Birmingham vasculitis activity score16; ESR = erythrocyte sedimentation rate; CRP = C reactive protein; BAL = bronchoalveolar lavage; NS = no significant difference.
The fraction of CD28– T cells within the CD4+ and CD8+ T cell populations is indicated by CD4+/CD28– and CD8+/CD28–.
↵1-151 p value indicates statistically significant differences between WG and sarcoidosis.
↵1-152 Frequencies of CD4+/CD28– and CD8+/CD28– T cells from peripheral venous blood and BAL fluid were also significantly different in WG (p<0.001 and p<0.01) but not in acute sarcoidosis.