Table 3

Cumulative results

AnalysisMean (SD)p value
LAMControl
COMT activity3-150 24.2 (6.3)24.2 (12.4)0.996
COMT inhibitor in plasma3-160
 10 μl0.48 (0.12)0.43 (0.20)0.44
 50 μl0.36 (0.10)0.31 (0.13)0.30
MDA (pmol/ml plasma)178.5 (80.1)155.4 (75.0)0.40

  • ↵3-150 COMT activity = pmol 4-hydroxy-3-methoxybenzoic acid formed per minute per mg protein.

  • ↵3-160 A plasma volume of 10 μl or 50 μl was added to 12 units of a commercial preparation of COMT. COMT activity without plasma = 4.35 pmol 4-hydroxy-3-methoxybenzoic acid formed per minute.