Type of involvement | Other names | Age at onset | Tissues commonly involved | Prognosis | ||||
Diffuse | Letterer-Siwe disease | Infants (<2 years) Elderly | Skin, bone, bone marrow, lung, liver, spleen, lymph nodes, thymus, hypophysis, other | Often poor | ||||
Multifocal | Multifocal eosinophilic granuloma | Children and adolescents | Bone, skin, lung, meninges, pituitary, lymph nodes | Variable, often favourable | ||||
Hand-Schüller-Christian syndrome | ||||||||
Localised | Eosinophilic granuloma | Young adults | Bone, lung, (skin) | Usually favourable | ||||
Pulmonary Langerhans' cell histiocytosis |