Adverse events
| Tiotropium (n = 191) | Ipratropium (n = 97) | |
| Total with any adverse event | 129 (67.5) | 62 (63.9) |
| General | ||
| Chest pain | 5 (2.6) | 0 |
| Fatigue | 4 (2.1) | 1 (1.0) |
| Headache | 10 (5.2) | 10 (10.3) |
| Influenza-like symptoms | 6 (3.1) | 8 (8.2) |
| Pain, non-site specific | 4 (2.1) | 1 (1.0) |
| Upper respiratory | ||
| Dry mouth | 28 (14.7) | 10 (10.3) |
| Pharyngitis | 6 (3.1) | 0 |
| Upper respiratory tract infection | 35 (18.3) | 11 (11.3) |
| Lower respiratory | ||
| COPD exacerbation | 21 (11.0) | 12 (12.4) |
| Cough | 5 (2.6) | 5 (5.2) |
| Pneumonia | 5 (2.6) | 2 (2.1) |
Values are number (%) of patients. No significant differences were seen between the two groups.