Risk of adult onset wheeze and atopy according to sibship structure: adjusted odds ratios (95% confidence intervals)
|
Wheeze4-150
(n=94) |
Wheeze + asthma4-150 (n=22) |
Wheeze + cough/phlegm4-150 (n=27) | Atopy positive4-151 (n=150) | |
| Number of older siblings | ||||
| 1 | 1.0 (0.5 to 2.0) | 2.2 (0.6 to 7.9) | 1.1 (0.4 to 3.6) | 0.9 (0.5 to 1.6) |
| 2 | 1.1 (0.5 to 2.3) | 2.3 (0.5 to 9.9) | 0.7 (0.2 to 2.8) | 0.8 (0.4 to 1.5) |
| 3 or more | 0.6 (0.3 to 1.4) | 1.1 (0.2 to 5.9) | 0.4 (0.1 to 1.9) | 0.8 (0.4 to 1.8) |
| Number of younger siblings | ||||
| 1 | 1.0 (0.6 to 1.9) | 0.9 (0.3 to 2.6) | 1.0 (0.3 to 3.4) | 0.9 (0.5 to 1.6) |
| 2 | 0.7 (0.3 to 1.5) | 0.1 (0.03 to 0.8)4-152 | 1.0 (0.2 to 3.9) | 2.3 (1.1 to 5.1) |
| 3 or more | 0.7 (0.3 to 1.8) | p for trend = 0.029 | 2.1 (0.5 to 8.4) | 1.2 (0.5 to 2.6) |
| Total number of siblings | ||||
| 1 | 1.1 (0.4 to 3.4) | 0.7 (0.1 to 3.0) | 1.6 (0.1 to 23.1) | 1.1 (0.4 to 3.0) |
| 2 | 0.6 (0.2 to 2.1) | 0.4 (0.1 to 2.1) | 1.6 (0.1 to 23.6) | 1.3 (0.5 to 3.7) |
| 3 | 0.6 (0.2 to 1.9) | 0.2 (0.03 to 1.4) | 1.4 (0.1 to 20.4) | 1.1 (0.4 to 3.1) |
| 4 or more | 0.6 (0.2 to 2.1) | 0.3 (0.04 to 2.0) | 1.1 (0.1 to 15.9) | 1.5 (0.5 to 4.2) |
↵4-150 Odds ratios are adjusted for sex, social class based on subject's own occupation, smoking habit, atopy, and family history of atopic disease.
↵4-151 Odds ratios are adjusted for sex, social class based on subject's own occupation, smoking habit, and family history of atopic disease.
↵4-152 Due to small numbers, “younger siblings” was recoded as 0, 1, 2 or more in this model.