Mean (SE) results of methotrexate versus prednisone in sarcoidosis24
| Methotrexate | Prednisone | ||||||
|---|---|---|---|---|---|---|---|
| Before treatment | After treatment | Before treatment | After treatment | ||||
| Vital capacity (l) | 2.4 (0.14) | 2.8 (0.18)1-151 | 2.5 (0.14) | 3.1 (0.18)1-151 | |||
| BAL lymphocyte (%) | 37 (3.4) | 16 (2.7)1-151 | 30 (3.5) | 16 (2.7)1-151 | |||
| BAL lymphocyte CD4:CD8 | 7.4 (2.69) | 4.0 (1.90) | 7.3 (1.52) | 3.3 (0.67) | |||
| Macrophage TNF release (units/106cells) | 111 (44.4) | 24 (15.4)‡ | 89 (29.2) | 18 (9.2)‡ | |||
BAL = bronchoalveolar lavage; TNF = tumour necrosis factor.
↵1-151 p<0.001, ‡p<0.05 versus before treatment.