Demographic characteristics of the study population and the intent-to-treat population
| Study population (n=75) | Intent-to-treat population (n=149) | ||||
|---|---|---|---|---|---|
| Ciprofloxacin (n=41) | Imipenem (n=34) | Ciprofloxacin (n=72) | Imipenem (n=77) | ||
| Men, n (%) | 31 (75.6%) | 25 (73.5%) | 53 (73.6%) | 57 (74.0%) | |
| Women, n (%) | 10 (24.4%) | 9 (26.5%) | 19 (26.4%) | 20 (26.0%) | |
| Mean (SD) age (years) | 64 (14) | 61 (17) | 60 (16) | 62 (16) | |
| Mean (SD) weight (kg) | 74 (13) | 71 (10) | 72 (12) | 71 (11) | |
| Mean (SD) BMI (kg/m2) | 26.7 (4.6) | 25.9 (3.5) | 26.1 (4.0) | 26.0 (3.8) | |
| No with one or more comorbid illness | 41 (100%) | 30 (88%) | 70 (97%) | 71 (92%) | |
| Type of comorbid illness1-150, n (%) | |||||
| COPD | 16 (39%) | 12 (35%) | 20 (28%) | 29 (38%) | |
| Other respiratory illness | 3 (7%) | 1 (4%) | 2 (3%) | 2 (3%) | |
| Cardiovascular/vascular | 14 (34%) | 16 (47%) | 28 (39%) | 33 (43%) | |
| Neurological | 10 (24%) | 10 (29%) | 17 (24%) | 23 (30%) | |
| Diabetes mellitus | 6 (15%) | 6 (18%) | 9 (13%) | 7 (9%) | |
| Gastrointestinal | 9 (2%) | 3 (9%) | 10 (14%) | 4 (5%) | |
| Neoplasm | 7 (17%) | 0 | 12 (17%) | 4 (5%) | |
| Renal | 2 (5%) | 0 | 2 (3%) | 4 (5%) | |
| Other | 3 (7%) | 0 | 3 (4%) | 1 (1%) | |
| Mean (SD) P(A–a)o 2 | 218 (113) | 215 (154) | 257 (157) | 213 (144) | |
| Mean (SD) Pao 2/Fio 2 ratio | 206 (93) | 223 (86) | 204 (101) | 229 (124) | |
| Mean (SD) APACHE score | 13.8 (7.5) | 13.9 (8.6) | 13.9 (7.7) | 14.7 (7.6) | |
| Mean (SD) leucocyte count/mm 3 1-151 | 14.5 (5.9) | 12.6 (5.5) | 14.5 (5.6) | 12.6 (4.9) | |
| Mean (SD) creatinine (mg/dl) | 1.3 (1.2) | 0.9 (0.4) | 1.2 (1.1) | 1.0 (0.6) | |
| Mean (SD) body temperature (°C) | 37.8 (0.9) | 37.9 (1.1) | 37.8 (1.0) | 37.8 (0.9) | |
| Mean (SD) PEEP (cm H2O) (no (%) patients with PEEP) | 5.7 (2.8) (15 (36.6%)) | 5.7 (3.3) (17 (45.9%)) | 6.2 (3.1) (34 (47.2%)) | 6.0 (3.4) (29 (37.6%)) | |
| No (%) patients with PEEP ⩾5 cm H2O | 22 (53.7%) | 18 (52.9) | 38 (52.8%) | 36 (46.8) | |
BMI = body mass index; P(A–a)o 2 = alveolar-arterial oxygen tension gradient; Pao2 = arterial oxygen tension; Fio 2 = fractional inspired oxygen concentration; PEEP = positive end expiratory pressure required on enrollment to the study.
↵1-150 Sum of single percentages higher than 100% due to multiple comorbid illnesses.
↵1-151 Mann-Whitney U test, p = 0.165.