Significant differences between groups of COPD with values within and out of the range of healthy subjects for parameters that differ significantly between COPD and healthy subjects
| Differences between COPD and healthy subjects | Difference between groups of COPD | COPD out of range of healthy | COPD within range of healthy | p value | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Upper limit of range3-151 | Median (ranges) | n | Median (ranges) | n | |||||||
| Eosinophils | Biopsy | >40 cells/mm2 | CD4+ (cells/mm2) | 930 (560–1320) | 6 | 210 (100–1300) | 12 | 0.03 | |||
| Sputum | >3.1% | FEV1/VC (%) | 41 (34–58) | 5 | 53 (38–67) | 13 | 0.027 | ||||
| Serum eosinophils (cells/ml) | 420 (240–540) | 5 | 130 (30–350) | 13 | 0.002 | ||||||
| Sputum ECP (ng/ml) | 1834 (1105–4530) | 5 | 332 (115–23760) | 13 | 0.021 | ||||||
| Sputum ECP/eosinophils (ng/ml) | 9.4 (5.9–15.1) | 5 | 35.5 (5.8–43.4) | 13 | 0.037 | ||||||
| BAL | >0.45% | NP57+ (cells/mm2) | 220 (120–590) | 6 | 670 (10–1250) | 10 | 0.034 | ||||
| Macrophages | Biopsy | >1580 cells/mm2 | CD4+ (cells/mm2) | 1220 (530–1320) | 5 | 335 (100–960) | 13 | 0.015 | |||
| Neutrophils | Sputum | >60% | Sputum IL-8 (pg/ml) | 23 (4–1300) | 13 | 7 (4–17) | 5 | 0.027 | |||
| Sputum ECP (ng/ml) | 1510 (274–23760) | 13 | 250 (115–1105) | 5 | 0.012 | ||||||
| Sputum epithelial cells (%) | 0 (0–1.1) | 13 | 1.4 (0.5–2.8) | 5 | 0.001 | ||||||
↵3-151 Of values in healthy subjects.