Influence of disease severity on likelihood of transmission of the –251A allele
| Marker of severity | n | T | NT | %T (95% CI) | p value |
|---|---|---|---|---|---|
| All infants | 83 | 69 | 43 | 62 (53 to 71) | 0.014 |
| Infants needing oxygen | 53 | 45 | 24 | 65 (54 to 76) | 0.011 |
| Infants needing >2 days oxygen | 35 | 32 | 13 | 71 (58 to 84) | 0.005 |
| Infants needing mechanical ventilation | 7 | 7 | 3 | 70 (42 to 98) | 0.206 |
n = number of informative probands; T = transmitted; NT = non-transmitted; %T = percentage of –215A alleles transmitted. The p values, based on Pearson's test statistic, reflect the significance of the deviation of the % transmission from the expected 50%.