Major subsets | Name | MMP no. | Major substrates |
---|---|---|---|
Classic matrix metalloproteinase (MMP) members: | |||
Collagenases | Interstitial collagenase (fibroblast type) | MMP-1 | Fibrillar collagens |
Neutrophil collagenase | MMP-8 | Fibrillar collagens | |
Collagenase-3 | MMP-13 | Fibrillar collagens | |
Stromelysins | Stromelysin-1 | MMP-3 | Laminin, fibronectin, proteoglycans, type IV |
Stromelysin-2 | MMP-10 | collagens | |
Matrilysin | MMP-7 | Proteoglycans, type IV collagens, gelatins, ECM glycoproteins, elastin | |
Gelatinases | Gelatinase A | MMP-2 | Type I and IV collagens, gelatin |
Gelatinase B | MMP-9 | Type IV and V collagens, gelatin | |
Elastases | Metalloelastase | MMP-12 | Elastin |
? | MMP-18 | Elastin | |
? | MMP-19 | Elastin | |
Novel matrix metalloproeinase family members: | |||
RXKR secreted type | Stromelysin-3 | MMP-11 | Laminin, fibronectin, proteoglycans, alpha 1-antitrypsin |
RXKR membrane type | MT1-MMP | MMP-14 | Gelatinase A, fibrillar collagens, ECM glycoproteins, proteoglycans |
MT2-MMP | MMP-15 | ? | |
MT3-MMP | MMP-16 | Gelatinase A | |
MT4-MMP | MMP-17 | ? |
Adapted from Stetler-Stevenson et al 208 and Chambers et al.2